question in carcinoid syndrome

9/13/2014 5:13:56 AM
What this mean


5ht undergo first pass metabolism in liver
It mentioned in carcinoid syndrome in FA


9/16/2014 2:15:27 AM
first pass metabolism, which use liver P 450.which decrease some drugs effects.


9/19/2014 12:28:09 AM
drhassansurgeon wrote:
What this mean


5ht undergo first pass metabolism in liver
It mentioned in carcinoid syndrome in FA


it means that when carcinoid tumor is present in the liver then the S/S are not seen cuz the 5HT that it produces undergoes metabolism in the liver. when present outside the liver like in the GI tract thats when u see the flushing etc.. all the S/S.
an first pass metabolism per se means that the concentration of the drug is greatly reduced before reaching the systemic circulation since it is undergoing metabolism in the liver


9/19/2014 1:07:52 AM
If . the primary tumor is from the GI tract (hence releasing serotonin into the hepatic portal circulation), carcinoid syndrome generally does not occur until the disease is so advanced that it overwhelms the liver's ability to metabolize the released serotonin.

So carcinoid tumor to produce symptoms has to bypass the hepatic metabolism.


pages: 1

 | 
We use cookies to learn how you use our website and to ensure that you have the best possible experience.
By continuing to use our website, you are accepting the use of cookies. Learn More
   I Accept