Need an explaination!

saher
8/4/2013 4:30:15 PM
Hi,

can anyone explain me how hypothyroidism leads to hypogonadotropic hypogonadism?

Thanks in advance!


reinaliz
8/4/2013 6:55:10 PM
Hey,
With primary Hypothyroidism, there is a subsequent increase in TSH/TRH...this elevation causes dopamine inhibition which will then stimulate prolactin release causing decreased levels of GnRH.
Also, prolactin is stimulated by TRH and serotonin!


saher
8/4/2013 10:26:08 PM
reinaliz wrote:
Hey,
With primary Hypothyroidism, there is a subsequent increase in TSH/TRH...this elevation causes dopamine inhibition which will then stimulate prolactin release causing decreased levels of GnRH.
Also, prolactin is stimulated by TRH and serotonin!


thanks


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